Erythrocyte Membrane-Encapsulated Glucose Oxidase and Manganese/Ferrite Nanocomposite as a Biomimetic “All in One” Nanoplatform for Cancer Therapy
Ruijiao Sun, Yonghao Ge, Hongxing Liu, Peng He, Weiling Song, Xiaoru Zhang
Abstract
Recently, reactive oxygen species-participated multimodal synergistic therapy has shown great potential in tumor therapy. Herein, a biomimetic nanoplatform (MFG@RBCm) was constructed with a red blood cell membrane (RBCm) as a shell to encapsulate glucose oxidase and a manganese/ferrite nanocomposite. It integrated with long circulation and multimodal synergistic treatment (photothermal therapy, chemodynamic therapy, cancer starvation therapy, and photodynamic therapy) with magnetic resonance imaging, producing an “all in one” nanoplatform. The prepared nanocomposite was fully characterized, and the cooperative enhancement for multimodal synergistic therapy effect was investigated through in vitro and in vivo tests.