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Fluorine-18 labelled Ruppert–Prakash reagent ([<sup>18</sup>F]Me<sub>3</sub>SiCF<sub>3</sub>) for the synthesis of <sup>18</sup>F-trifluoromethylated compounds

Anna Pees, Maria J.W.D. Vosjan, Neil Vasdev, Albert D. Windhorst, Daniëlle J. Vugts

2021Chemical Communications17 citationsDOIOpen Access PDF

Abstract

This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [18F]Me3SiCF3. [18F]Me3SiCF3 was synthesized from [18F]fluoroform with radiochemical yields of 85-95% and radiochemical purities of >95% within 20 minutes. 18F-trifluoromethylated compounds were successfully prepared by reaction of [18F]Me3SiCF3 with benzaldehydes, acetophenones and benzophenones.

Topics & Concepts

ReagentFluorineRadiochemistryChemistryOrganic chemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSynthesis and Reactions of Organic Compounds
Fluorine-18 labelled Ruppert–Prakash reagent ([<sup>18</sup>F]Me<sub>3</sub>SiCF<sub>3</sub>) for the synthesis of <sup>18</sup>F-trifluoromethylated compounds | Litcius