In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways
Jin Lei, Jian Zhao, Meng-Yi-Chen Long, Xue‐Wei Cao, Fujun Wang
Topics & Concepts
EndosomeCell biologyProtein kinase BEndocytic cyclePI3K/AKT/mTOR pathwayChemistryCathepsin DSignal transductionMAPK/ERK pathwayBiologyEndocytosisCellBiochemistryIntracellularEnzymeToxin Mechanisms and ImmunotoxinsEndoplasmic Reticulum Stress and DiseaseLipid Membrane Structure and Behavior