Structural characterization of five functional states of metabotropic glutamate receptor 8
Jie Zhao, Yue Deng, Zheng Xu, Chanjuan Xu, Chang Zhao, Ziyan Li, Hui‐Chuan Sun, Xiaowen Tian, Yuxuan Song, Marta Cimadevila, Heli Wang, Yuxuan Liu, Xiaoyu Zhang, Yiyang Chen, Suyue Sun, Xihao Yong, Lantian Su, Yutian He, Yi Zhong, Hao Yang, Jean‐Philippe Pin, Wei Yan, Zhenhua Shao, Jianfeng Liu
Topics & Concepts
AgonistBiologyMetabotropic glutamate receptorMetabotropic glutamate receptor 2Allosteric regulationGlutamate receptorMetabotropic receptorCell biologyMetabotropic glutamate receptor 5ExtracellularG protein-coupled receptorReceptorMetabotropic glutamate receptor 1Signal transductionMetabotropic glutamate receptor 7Class C GPCRNeuroscienceMetabotropic glutamate receptor 6Drug discoveryBiochemistryMetabotropic glutamate receptor 4G proteinMetabotropic glutamate receptor 3DimerHEK 293 cellsBiophysicsFunctional selectivityProtein subunitReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchIon channel regulation and function