<i>In Vitro</i> and <i>In Vivo</i> Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin
Mahsa Bagheri, Marcel H.A.M. Fens, Tony G. Kleijn, Robin Capomaccio, Dóra Méhn, Przemek M. Krawczyk, Enzo M. Scutigliani, Andrei Gurinov, Marc Baldus, Nicky C.H. van Kronenburg, Robbert J. Kok, Michal Heger, Cornelus F. van Nostrum, Wim E. Hennink
Abstract
studies can be attributed to the interaction of curcumin with blood cells. Despite the excellent solubilizing effect of these micelles, no cytostatic effect was achieved in neuroblastoma-bearing mice, possibly because of the low sensitivity of the Neuro2A cells to curcumin.
Topics & Concepts
CurcuminMicelleChemistryEthylene glycolIn vivoChromatographyNuclear chemistryOrganic chemistryBiochemistryAqueous solutionBiologyBiotechnologyField-Flow Fractionation TechniquesNanoparticle-Based Drug DeliveryCurcumin's Biomedical Applications