Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids
Yue Cao, Shenghua Han, Han Zhang, Jie Wang, Qiaoyan Jiang, Yimin Zhou, Youjia Yu, Jianfang Wang, Feng Chen, Dennis K. P. Ng
Abstract
A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acids on the surface of cancer cells based on its dual surface-enhanced Raman scattering and fluorescence response. This biomarker can also trigger the photodynamic activity of these nanobipyramids, effectively eradicating the cancer cells mainly through apoptosis as shown by various bioassays.
Topics & Concepts
NanoprobeCancer cellFluorescenceMaterials sciencePhenylboronic acidSialic acidRaman scatteringPhotodynamic therapyNanotechnologyRaman spectroscopyChemistryCancerBiochemistryNanoparticleOrganic chemistryBiologyCatalysisQuantum mechanicsGeneticsPhysicsOpticsAdvanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and ApplicationsNanoplatforms for cancer theranostics