Targeting Wnt/β-catenin signaling using XAV939 nanoparticles in tumor microenvironment-conditioned macrophages promote immunogenicity
Chetan Pundkar, Ferrin Antony, Xuejia Kang, Amarjit Mishra, R. Jayachandra Babu, Pengyu Chen, Feng Li, Amol Suryawanshi
Abstract
T cell proliferation compared to Con-Np-treated macrophages. These data suggest that targeted β-catenin inhibition in TAMs represents a promising therapeutic approach to promote anti-tumor immunity.
Topics & Concepts
ImmunogenicityWnt signaling pathwayTumor microenvironmentCateninCell biologyChemistryCancer researchSignal transductionBiologyImmunologyTumor cellsImmune systemImmunotherapy and Immune ResponsesWnt/β-catenin signaling in development and cancerCancer Immunotherapy and Biomarkers