A Novel Transferable Resistance-Nodulation-Division Pump Gene Cluster, <i>tmexCD2-toprJ2</i> , Confers Tigecycline Resistance in Raoultella ornithinolytica
Cheng-Zhen Wang, Xun Gao, Qiwen Yang, Luchao Lv, Miao Wan, Jun Yang, Zhongpeng Cai, Jian–Hua Liu
Abstract
We recently identified a novel plasmid-mediated resistance-nodulation-division (RND)-type efflux pump gene cluster, tmexCD1-toprJ1 , in Klebsiella pneumoniae that conferred resistance to multiple antimicrobials, including tigecycline. While homologs of tmexCD1-toprJ1 were found encoded in many other bacterial species in GenBank, their functions and transfer mechanisms remain unknown.
Topics & Concepts
BiologyPlasmidMicrobiologyTigecyclineGeneticsRecombinaseGene clusterKlebsiella pneumoniaeEscherichia coliGeneOperonAntimicrobialRecombinationAntibiotic Resistance in BacteriaEnterobacteriaceae and Cronobacter ResearchPneumocystis jirovecii pneumonia detection and treatment