Transition‐Metal‐Free Cross‐Coupling by Using Tertiary Benzylic Organoboronates
Mitsutaka Takeda, Kazunori Nagao, Hirohisa Ohmiya
Abstract
The transition-metal-free cross-coupling of alkyl or aryl electrophiles by using tertiary benzylic organoboronates is reported. This reaction involves the generation of tertiary alkyl anions from organoboronates in the presence of an alkoxide base and then their substitution reactions. This protocol allows the simple and efficient construction of quaternary carbon centers.
Topics & Concepts
Transition metalCoupling (piping)ChemistryMaterials scienceMetallurgyOrganic chemistryCatalysisCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions