100% atom-economical and highly regio- and stereoselective iodosulfenylation of alkynes: a reagentless and sustainable approach to access (<i>E</i>)-β-iodoalkenyl sulfides and (<i>Z</i>)-tamoxifen
Appanapalli N. V. Satyanarayana, Nilanjana Mukherjee, Tanmay Chatterjee
Abstract
A 100% atom-economical iodosulfenylation of alkynes is developed using only iodine and disulfides via the in situ formation of the corresponding sulfenyl iodide intermediates to access ( E )-β-iodoalkenyl sulfides and ( Z )-tamoxifen.
Topics & Concepts
StereoselectivityIodideChemistryIodineAtom (system on chip)TamoxifenCombinatorial chemistryCatalysisMedicinal chemistryOrganic chemistryComputer scienceCancerEmbedded systemBreast cancerMedicineInternal medicineSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsVanadium and Halogenation Chemistry