Design, synthesis, biological evaluation and molecular modelling studies of conophylline inspired novel indolyl oxoacetamides as potent pancreatic lipase inhibitors
S. N. C. Sridhar, Saksham Palawat, Atish T. Paul
Abstract
Twenty-one indolyl oxoacetamides were designed and synthesized inspired by conophylline. Analogues <bold>12c</bold> and <bold>12b</bold> with <italic>N</italic>-geranyl substitution on indole exhibited potent pancreatic lipase inhibition.
Topics & Concepts
ChemistryPancreatic lipaseIndole testLipaseSubstitution (logic)StereochemistryBiochemistryEnzymeProgramming languageComputer scienceSynthesis and Biological EvaluationChemical synthesis and alkaloidsCancer therapeutics and mechanisms