Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties
Shihao Hu, Amita Datta‐Mannan, David Z. D’Argenio
Abstract
measures of antibody physiochemical properties, and can be expanded to include more descriptive representations of each of the antibody processing subsystems, as well as other antibody-specific information.
Topics & Concepts
AntibodyMonoclonal antibodyIn vitroChemistryPharmacokineticsPhysiologically based pharmacokinetic modellingIn vivoIn vitro toxicologyPharmacologyBiophysicsImmunologyBiochemistryMedicineBiologyBiotechnologyMonoclonal and Polyclonal Antibodies ResearchProtein purification and stabilityBlood groups and transfusion