Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors
Ghaneya S. Hassan, Hanan H. Georgey, Esraa Z. Mohammed, Riham F. George, Walaa R. Mahmoud, Farghaly A. Omar
Topics & Concepts
ChemistryCyclin-dependent kinase 2Cyclin-dependent kinase 1Quantitative structure–activity relationshipIC50StereochemistryDocking (animal)ApoptosisCell cycle checkpointSelectivityCell growthCell cycleGrowth inhibitionDoxorubicinPyrazoleCell cultureCaspase 3BiochemistryIn vitroProgrammed cell deathInternal medicineChemotherapyMedicineGeneticsNursingBiologyCatalysisCancer-related Molecular PathwaysCancer Mechanisms and TherapyCancer therapeutics and mechanisms