Discovery of novel phenyl triazole analogs as TRK/ALK dual inhibitors with prospective antitumor effects
Zhi Cao, Jiahao Zhang, Mengrao Guo, Bin Shao, Xiujian Wei, Sen Li, Peng Wang, Xin Zhai
Topics & Concepts
Trk receptorChemistryAnaplastic lymphoma kinaseMoietyMTT assayKinaseTropomyosin receptor kinase AIC50CytotoxicityPharmacologyCancer researchCell growthIn vitroStereochemistryReceptorBiochemistryInternal medicineBiologyMedicineMalignant pleural effusionNeurotrophinPleural effusionNerve growth factorCancer therapeutics and mechanismsLung Cancer Treatments and MutationsQuinazolinone synthesis and applications