Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses
Yiliang Wang, Yun Wang, Weisheng Luo, Xiaowei Song, Lianzhou Huang, Ji Xiao, Fujun Jin, Zhe Ren, Yifei Wang
Abstract
A machinery components, TRIM family members, and even the DNA binding factors recognized traditionally, function in innate antiviral response. In this review, we highlight recent progress in the regulation of type I interferon signaling-based antiviral responses by lncRNAs and emerging RBPs as well as their mechanism of actions. We then posed the future perspective toward the role of lncRNA-RBP interaction networks in innate antiviral response and discussed the promising and challenges of lncRNA-based drug development as well as the technical bottleneck in studying lncRNA-protein interactions. Our review provides a comprehensive understanding of lncRNA and emerging RBPs in the innate antiviral immune response.