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Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

Shan Lu, Jiaojiao Hu, Olubankole Aladesuyi Arogundade, Alexander Goginashvili, Sonia Vazquez‐Sanchez, Jolene K. Diedrich, Jinge Gu, Jacob A. Blum, Spencer Oung, Qiaozhen Ye, Haiyang Yu, John Ravits, Cong Liu, John R. Yates, Don W. Cleveland

2022Nature Cell Biology158 citationsDOIOpen Access PDF

Topics & Concepts

Heat shock proteinChaperone (clinical)CytoplasmCell biologyPhase transitionChemistryBiophysicsBiochemistryBiologyThermodynamicsPhysicsGenePathologyMedicineHeat shock proteins researchGenetics, Aging, and Longevity in Model OrganismsEndoplasmic Reticulum Stress and Disease
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition | Litcius