A novel DNA aptamer targeting lung cancer stem cells exerts a therapeutic effect by binding and neutralizing Annexin A2
Yi-Ying Wu, I‐Shan Hsieh, Chia-Hao Tung, Chen-Hsun Weng, Jiaen Wu, Jau‐Song Yu, Tse-Ming Hong, Yuh‐Ling Chen
Abstract
. The present findings suggest that Annexin A2 is a CSC marker and regulator, and the CSC-specific aptamer AP-9R has potential theranostic applications for lung cancer.
Topics & Concepts
AptamerSystematic evolution of ligands by exponential enrichmentCancer stem cellLung cancerCancer researchAnnexin A2A549 cellCancer cellCancerAnnexinBiologyMolecular biologyChemistryStem cellCell biologyMedicineRNAPathologyBiochemistryFlow cytometryGeneticsGeneAdvanced biosensing and bioanalysis techniquesAntimicrobial Peptides and ActivitiesRNA Interference and Gene Delivery