Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer
Ming‐Shou Hsieh, Hang Ling, Syahru Agung Setiawan, Mardiah Suci Hardianti, Iat-Hang Fong, Chi‐Tai Yeh, Jia‐Hong Chen
Topics & Concepts
AuranofinCancer researchThioredoxin reductaseRibonucleotide reductaseCancer cellHead and neck squamous-cell carcinomaThioredoxinChemistryCancerMedicineImmunologyOxidative stressHead and neck cancerInternal medicineBiochemistryGeneProtein subunitRheumatoid arthritisFerroptosis and cancer prognosisCancer Immunotherapy and BiomarkersEpigenetics and DNA Methylation