Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
Luise Linsenmeier, Behnam Mohammadi, Mohsin Shafiq, Karl Frontzek, Julia Bär, Amulya Nidhi Shrivastava, Markus Daμμe, Feizhi Song, Alexander Schwarz, Stefano Da Vela, Tania Massignan, Sebastian Jung, Angela da Silva Correia, Matthias Schmitz, Berta Puig, Simone Hornemann, Inga Zerr, Jörg Tatzelt, Emiliano Biasini, Paul Säftig, Michaela Schweizer, Dmitri I. Svergun, Ladan Amin, Federica Mazzola, Luca Varani, Simrika Thapa, Sabine Gilch, Hermann Schätzl, David A. Harris, Antoine Triller, Marina Mikhaylova, Adriano Aguzzi, Hermann C. Altmeppen, Markus Glatzel
Abstract
. Both mechanisms may contribute to beneficial actions described for PrP-directed ligands and pave the way for new therapeutic strategies against currently incurable neurodegenerative diseases.