Proteasome activator PA200 maintains stability of histone marks during transcription and aging
Tian-Xia Jiang, Shuang Ma, Xia Han, Zi-Yu Luo, Qianqian Zhu, Tomoki Chiba, Wei Xie, Kui Lin, Xiao‐Bo Qiu
Abstract
PA200 promotes the transcription-coupled degradation of the core histones, and plays an important role in maintaining the stability of histone marks during transcription and aging.
Topics & Concepts
ProteasomeHistoneCell biologyTranscription (linguistics)AcetylationTranscription factorBiologyChemistryGeneticsDNAGenePhilosophyLinguisticsUbiquitin and proteasome pathwaysGenetics and Neurodevelopmental DisordersHistone Deacetylase Inhibitors Research