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Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Michael V. Zuccaro, Jia Xu, Carl A. Mitchell, Diego Marín, Raymond Zimmerman, Bhavini Rana, Everett Weinstein, Rebeca T. King, Katherine L. Palmerola, Morgan Elizabeth Smith, Stephen H. Tsang, Robin Goland, Maria Jasin, Rogerio A. Løbo, Nathan R. Treff, Dieter Egli

2020Cell324 citationsDOIOpen Access PDF

Topics & Concepts

BiologyFrameshift mutationGeneticsZygoteAlleleMitosisLocus (genetics)EmbryoMutationGeneEmbryogenesisCRISPR and Genetic EngineeringChromosomal and Genetic VariationsPluripotent Stem Cells Research
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