Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos
Michael V. Zuccaro, Jia Xu, Carl A. Mitchell, Diego Marín, Raymond Zimmerman, Bhavini Rana, Everett Weinstein, Rebeca T. King, Katherine L. Palmerola, Morgan Elizabeth Smith, Stephen H. Tsang, Robin Goland, Maria Jasin, Rogerio A. Løbo, Nathan R. Treff, Dieter Egli
Topics & Concepts
BiologyFrameshift mutationGeneticsZygoteAlleleMitosisLocus (genetics)EmbryoMutationGeneEmbryogenesisCRISPR and Genetic EngineeringChromosomal and Genetic VariationsPluripotent Stem Cells Research