New thiazolidine-2,4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity studies
Hazem Elkady, Abdelrahman A. Abuelkhir, Mahmoud Rashed, Mohammed S. Taghour, Mohammed A. Dahab, Hazem A. Mahdy, Alaa Elwan, Hanan Al-Ghulikah, Eslam B. Elkaeed, Ibrahim M. Ibrahim, Dalal Z. Husein, Ahmed M. Metwaly, Ibrahim H. Eissa
Topics & Concepts
Docking (animal)ChemistryIn vitroMolecular dynamicsStereochemistryIC50Cell cycleCombinatorial chemistryApoptosisBiochemistryComputational chemistryMedicineNursingBioactive Compounds and Antitumor AgentsAngiogenesis and VEGF in CancerSynthesis and biological activity