Fabrication of self-assembled nanostructures for intracellular drug delivery from diphenylalanine analogues with rigid or flexible chemical linkers
Amutha Arul, Priya Rana, Kiran Das, Ieshita Pan, Debasish Mandal, Adele Stewart, Biswanath Maity, Soumyajit Ghosh, Priyadip Das
Abstract
ethylenediamine and nanorods fabricated from terephthalaldehyde linked FF dipeptides were able to encapsulate the cancer chemotherapeutic agent doxorubicin (DOX) and chaperone the drug into cells. Thus, these supramolecular assemblies represent a new platform for the development of efficient and effective intracellular drug delivery systems.
Topics & Concepts
DipeptideDrug deliveryFabricationNanotechnologyNanostructureMaterials scienceIntracellularSelf-assemblyCombinatorial chemistryChemistryPeptideBiochemistryMedicineAlternative medicinePathologySupramolecular Self-Assembly in MaterialsRNA Interference and Gene DeliveryPolydiacetylene-based materials and applications