<i>Bifidobacterium longum</i>CCFM752 prevented hypertension and aortic lesion, improved antioxidative ability, and regulated the gut microbiome in spontaneously hypertensive rats
Wenwei Lu, Yusheng Wang, Zhifeng Fang, Hongchao Wang, Jinlin Zhu, Qixiao Zhai, Jianxin Zhao, Hao Zhang, Wei Chen
Abstract
at the genus level. Furthermore, serum metabolomic analysis revealed that CCFM752 up-regulated serum proline and pyridoxamine 5'-phosphate, both of which were negatively correlated with blood pressure. In conclusion, the positive impact of CCFM752 on the gut microbiota may contribute to the antioxidative effect as well as its preventive effect on hypertension.
Topics & Concepts
Blood pressureBifidobacterium longumBifidobacteriumGut floraOxidative stressFirmicutesCatalaseDysbiosisMedicineEndothelial dysfunctionEndocrinologyLactobacillusInternal medicineChemistryImmunologyFood scienceBiochemistryFermentation16S ribosomal RNAGeneGut microbiota and healthMetabolomics and Mass Spectrometry StudiesNeurological Disease Mechanisms and Treatments