Programmed pH-responsive core–shell nanoparticles for precisely targeted therapy of ulcerative colitis
Guangshuai Zhang, Wen Han, Peixu Zhao, Zijun Wang, Mo Li, Xiaofan Sui, Yanhua Liu, Baocheng Tian, Zhonggui He, Qiang Fu
Abstract
anti-inflammatory ability, and enhanced accumulation at the site of inflammation in the colon. Furthermore, after oral administration, CNs@EPO@L100 significantly ameliorated the inflammatory symptoms in mice. Taken together, this study provides insights into programmed release through the rational application of pH-sensitive materials and offers strategies for a precisely targeted therapy of UC using core-shell nanoparticles.
Topics & Concepts
Ulcerative colitisShell (structure)Core (optical fiber)NanoparticleNanotechnologyMaterials scienceMedicineInternal medicineDiseaseComposite materialInflammatory Bowel DiseaseNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems