Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities
Jiaoli Ding, Jing Liu, Zhipeng Zhang, Jie Guo, Maojun Cheng, Yang Wan, Rikang Wang, Yuanying Fang, Zhiyu Guan, Yi Jin, Sai‐Sai Xie
Topics & Concepts
HeLaChemistryHDAC1Histone deacetylaseCoumarinAcetylationHDAC6Histone deacetylase inhibitorIC50Docking (animal)Cell cycleHDAC8Cancer cellCell cultureApoptosisCell growthCell cycle checkpointHistoneBiochemistryCellIn vitroCancerBiologyGeneOrganic chemistryNursingMedicineGeneticsHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis