A 3D-printed microfluidic gradient generator with integrated photonic silicon sensors for rapid antimicrobial susceptibility testing
Christopher Heuer, John‐Alexander Preuß, Marc Buttkewitz, Thomas Scheper, Ester Segal, Janina Bahnemann
Abstract
and ciprofloxacin as a model pathogen-drug combination, we successfully determine the minimum inhibitory concentration within less than 90 minutes. This gradient generator-based PRISM assay provides an integrated AST device that is viable for convenient point-of-care testing and offers a promising and most importantly, rapid alternative to current clinical practices, which extend to 8-24 h.
Topics & Concepts
MicrofluidicsPhotonicsMaterials scienceGenerator (circuit theory)NanotechnologyOptoelectronicsPhysicsQuantum mechanicsPower (physics)Bacterial Identification and Susceptibility TestingBiosensors and Analytical DetectionMicrofluidic and Capillary Electrophoresis Applications