Design, synthesis, and cytotoxicity screening of novel pyrazolopyrimidines over renal cell carcinoma (UO-31 cells) as p38α inhibitors, and apoptotic cells inducing activities
Mohammed K. Abdelhameid, Amr Sonousi, Aliaa M. Kamal, Mohammed E. Abdel‐Hamid
Topics & Concepts
CytotoxicityChemistryApoptosisp38 mitogen-activated protein kinasesCell cultureCarcinomaCancer researchIn vitroBiochemistryInternal medicineMAPK/ERK pathwayKinaseBiologyMedicineGeneticsCancer Mechanisms and TherapyMelanoma and MAPK PathwaysSynthesis and biological activity