Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs)
Esraa Z. Mohammed, Walaa R. Mahmoud, Riham F. George, Ghaneya S. Hassan, Farghaly A. Omar, Hanan H. Georgey
Topics & Concepts
Cyclin-dependent kinase 1ChemistryCyclin-dependent kinaseCyclin-dependent kinase 2KinaseGrowth inhibitionPyrazoleCDK inhibitorCell growthCell cycleFlow cytometryDocking (animal)Cell cultureIC50BiochemistryIn vitroStereochemistryMolecular biologyApoptosisBiologyNursingMedicineGeneticsCancer-related Molecular PathwaysCancer Mechanisms and TherapyAdvanced Breast Cancer Therapies