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Characterization of novel heterocyclic compounds based on 4-aryl-4H-chromene scaffold as anticancer agents: Design, synthesis, antiprofilerative activity against resistant cancer cells, dual β-tubulin/c-Src inhibition, cell cycle arrest and apoptosis induction

Eman K.A. Abdelall, Heba A. H. Elshemy, Madlen B. Labib, Fatma E. A. Mohamed

2021Bioorganic Chemistry24 citationsDOI

Topics & Concepts

ChemistryStaurosporineApoptosisCell cycleCell cycle checkpointCytotoxicityCytotoxic T cellCell growthCell cultureKinaseDoxorubicinCellPopulationMTT assayCell biologyG1 phaseVinblastineBiochemistryCancer cellProgrammed cell deathCyclin-dependent kinase 2Cancer researchGrowth inhibitionMolecular biologyProtein kinase ASynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis and Biological Activity
Characterization of novel heterocyclic compounds based on 4-aryl-4H-chromene scaffold as anticancer agents: Design, synthesis, antiprofilerative activity against resistant cancer cells, dual β-tubulin/c-Src inhibition, cell cycle arrest and apoptosis induction | Litcius