Integration of Enzymatic Labeling with Single-Molecule Detection for Sensitive Quantification of Diverse DNA Damages
Yan Zhang, Ruo-nan Hua, Chun‐yang Zhang
Abstract
%. Importantly, it can provide information about the occurrence of DNA damage in a specific gene and ascertain the DNA damage level in different cancer cell lines, offering a new approach for studying the physiological function of various DNA damages in human diseases.
Topics & Concepts
DNA damageDNAChemistryTerminal deoxynucleotidyl transferaseOligonucleotideMolecular biologyGeneComputational biologyBiochemistryBiologyTUNEL assayApoptosisAdvanced biosensing and bioanalysis techniquesDNA Repair MechanismsDNA and Nucleic Acid Chemistry