Multidrug-Resistant Plasmodium falciparum Parasites in the Central Highlands of Vietnam Jeopardize Malaria Control and Elimination Strategies
Huynh Hong Quang, Marina Chavchich, Nguyễn Thị Minh Trinh, Kimberly A. Edgel, Michael D. Edstein, Nicholas J. Martin
Abstract
Plasmodium falciparum resistance to dihydroartemisinin-piperaquine has spread through the Greater Mekong Subregion to southwestern Vietnam. In 2018 to 2019, we collected 127 P. falciparum isolates from Dak Nong (36), Dak Lak (55), Gia Lai (13), and Kon Tum (23) provinces in Vietnam’s Central Highlands and found parasites bearing the Pfkelch13 C580Y mutation and multiple plasmepsin 2/3 genes (mean prevalence, 17.9%; range, 4.3% to 27.8%), conferring resistance to dihydroartemisinin-piperaquine.
Topics & Concepts
PiperaquinePlasmodium falciparumMalariaBiologyVirologyDihydroartemisininCentral HighlandsArtemisininImmunologyEcologyMalaria Research and ControlMosquito-borne diseases and controlDrug-Induced Hepatotoxicity and Protection