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Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy

Digambar Kumar Waiker, Akash Verma, T A Gajendra, NAMRATA NAMRATA, Anima Roy, Pradeep Kumar, Surendra Kumar Trigun, Saripella Srikrishna, Sairam Krishnamurthy, V. Jo Davisson, Sushant K. Shrivastava

2024European Journal of Medicinal Chemistry12 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryDonepezilIC50In vivoDYRK1APharmacologyLead compoundStereochemistryCholinesteraseInhibitory postsynaptic potentialEx vivoBiochemistryIn vitroKinaseDementiaNeuroscienceDiseaseInternal medicinePsychologyBiologyMedicineBiotechnologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy | Litcius