Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy
Digambar Kumar Waiker, Akash Verma, T A Gajendra, NAMRATA NAMRATA, Anima Roy, Pradeep Kumar, Surendra Kumar Trigun, Saripella Srikrishna, Sairam Krishnamurthy, V. Jo Davisson, Sushant K. Shrivastava
Topics & Concepts
ChemistryDonepezilIC50In vivoDYRK1APharmacologyLead compoundStereochemistryCholinesteraseInhibitory postsynaptic potentialEx vivoBiochemistryIn vitroKinaseDementiaNeuroscienceDiseaseInternal medicinePsychologyBiologyMedicineBiotechnologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity