Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Their Use in Synthesis
Zeyu Shi, Si Chen, Qiong Xiao, Dali Yin
Abstract
-mediated cyclization followed by a Cannizzaro reaction has been developed for the synthesis of various xanthene derivatives. The reaction proceeded smoothly to afford both xanthenes/xanthones or their sulfur derivatives and tolerated a wide range of electronically diverse substrates. Using this methodology, pranoprofen was synthesized in three steps in 59% overall yield from commercially available starting materials.
Topics & Concepts
XantheneChemistryYield (engineering)DisproportionationCombinatorial chemistryOrganic chemistryCatalysisMaterials scienceMetallurgySynthesis of Organic CompoundsNatural Compound Pharmacology StudiesSynthesis of Indole Derivatives