A metal‐free visible light promoted three‐component facile synthesis of 4‐oxo‐tetrahydroindoles in ethanol–water
Khursheed Ansari, Mohd Nazeef, Shabir Ali, Malik A. Waseem, Wajaht A. Shah, Saif Ansari, I. R. Siddiqui, Jagdamba Singh
Abstract
Abstract A mild and efficient visible light–mediated one‐pot multicomponent tandem approach to construct 4‐oxo‐tetrahydroindoles in ethanol–water medium at room temperature has been described. The characteristics of reported methodology are the utilization of visible light, an ideal source of energy to generate CC and CN bonds from commercially available substrates namely dimedone, phenacyl bromides, and amines. The presented protocol is highly compatible for developing 4‐oxo‐tetrahydroindole derivatives with improved selectivity and high yields. Moreover, metal‐free synthesis, environmental friendly solvent, easy workup process, high atom economy, cost‐effectiveness, short reaction time, and broad substratescope are the major advantages of reported protocol.