Multi-Omics Integration Reveals the Crucial Role of <i>Fusobacterium</i> in the Inflammatory Immune Microenvironment in Head and Neck Squamous Cell Carcinoma
Han Qiao, Hui Li, Xian-Hui Wen, Xi-Rong Tan, Chongzhe Yang, Na Liu
Abstract
Studies on revealing the composition and potential mechanisms of the tumor microbiome are still at an initial stage. We uncovered the potential contribution of the tumor-resident microbiota on the immunosuppressive microenvironment in HNSC, which will provide a new perspective for tumor microbiome research and yield valuable insights into the clinical management of HNSC.
Topics & Concepts
MicrobiomeTumor microenvironmentBiologyHead and neck squamous-cell carcinomaFusobacteriumCancerImmune systemTumor progressionCancer researchHead and neck cancerImmunologyBioinformaticsBacteroidesBacteriaGeneticsGut microbiota and healthImmune cells in cancerPancreatic and Hepatic Oncology Research