High hsa_circ_0020123 expression indicates poor progression to non-small cell lung cancer by regulating the miR-495/HOXC9 axis
Rui Bi, Wei Wei, Yunhui Lu, Fengqing Hu, Xuhui Yang, Yuan Zhong, Lifei Meng, Mingsong Wang, Jiang Lianyong, Xiao Xie
Abstract
. HOXC9 overexpression reversed miR-495-induced inhibition of cell migration and proliferation. The dual luciferase reporter assay demonstrated that hsa_circ_0020123 interacted with miR-495 by binding to the HOXC9 3'-UTR to suppresses post-transcriptional HOXC9 expression. Taken together, our study found that hsa_circ_0020123 functioned like a tumor promoter via a novel hsa_circ_0020123/miR-495/HOXC9 axis, highlighting its possibility as a new NSCLC therapeutic target.
Topics & Concepts
Gene knockdownDownregulation and upregulationGene silencingLuciferaseCancer researchCell growthChemistryMolecular biologyReporter geneIn vitroBiologyTransfectionGene expressionGeneBiochemistryCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation