An isoproteic cocoa butter-based ketogenic diet fails to improve glucose homeostasis and promote weight loss in obese mice
Amanda A. Greenwell, Christina T. Saed, Seyed Amirhossein Tabatabaei Dakhili, Kim L. Ho, Keshav Gopal, Jordan S. F. Chan, Oksana O. Kaczmar, Scott A. Dyer, Farah Eaton, Gary D. Lopaschuk, Rami Al Batran, John R. Ussher
Abstract
It has been demonstrated that ketogenic diets may be a nutritional strategy for alleviating hyperglycemia and promoting weight loss in obesity. However, there are a number of inconsistencies with many of these studies, especially with regard to the macronutrient and micronutrient compositions of the diets being compared. Our work demonstrates that a ketogenic diet that is both micronutrient-matched and isoproteic with its comparator diets fails to improve glycemia or promote weight loss in obese mice.
Topics & Concepts
Ketogenic dietObesityGlucose homeostasisWeight lossEndocrinologyInternal medicineCarbohydrateMicronutrientEnergy homeostasisMedicineBiologyFood scienceInsulin resistanceEpilepsyPsychiatryPathologyDiet and metabolism studiesAdipose Tissue and MetabolismDiet, Metabolism, and Disease