Visible Light-Induced, Persulfate-Promoted Synthesis of 2 Haloglycals from Glycals
Pallavi Saha, Deepak K. Sharma
Abstract
-mediated one-step synthesis of 2-halo glycals has been reported, employing potassium salts as halogen source (KI, KBr, and KCl). Versatility of the proposed methodology to generate chloro-, bromo-, and iodo-substituted d-glycals containing both aliphatic and aromatic substitutions emphasizes the reproducibility of the methodology. The synthesized halogenated derivatives were subjected to Suzuki, Heck, and Sonogashira cross-coupling reactions, showcasing the utility of the halogenated derivatives for subsequent C-2 functionalization reactions of d-glycals.
Topics & Concepts
ChemistrySonogashira couplingHalogenationHalogenOrganic chemistryCombinatorial chemistrySurface modificationCatalysisChemical synthesisBromineChlorineReaction conditionsPotassiumChlorinated solventsBenzene derivativesCarbohydrate Chemistry and SynthesisFluorine in Organic ChemistrySulfur-Based Synthesis Techniques