Convenient tumor 3D spheroid arrays manufacturing <i>via</i> acoustic excited bubbles for <i>in situ</i> drug screening
Jingjing Zheng, Xuejia Hu, Xiaoqi Gao, Yantong Liu, Shukun Zhao, Longfei Chen, Guoqing He, Jingwei Zhang, Lei Wei, Yi Yang
Abstract
, so that the cell spheroids response to drugs can be monitored conveniently and efficiently. This one-step tumor spheroids manufacturing method significantly reduces the model construction time to less than 15 s and increases efficiency by eliminating additional transfer processes. These significant advantages of convenience and high-throughput manufacturing make the tumor models promising for use in tumor treatment and point-of-care diagnosis.
Topics & Concepts
SpheroidIn situMicrofluidicsMaterials scienceExcited stateDrugNanotechnologyBiomedical engineeringOptoelectronicsChemistryEngineeringPhysicsBiologyIn vitroAtomic physicsOrganic chemistryBiochemistryPharmacologyMicrofluidic and Bio-sensing Technologies3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications