Developing an atroposelective dynamic kinetic resolution of MRTX1719 by resolving incompatible chemical operations
Michał Achmatowicz, Cheng‐yi Chen, David R. Snead
Abstract
continuous processing. Application toward synthesis of MRTX1719, a densely functionalized active pharmaceutical ingredient (API), improved yield from 37% to 87%. This protocol provides a complementary means to access rotamers which challenge current asymmetric methodologies, and greatly improves sustainability by decreasing the consumption of solvent and advanced synthetic intermediates.
Topics & Concepts
Kinetic resolutionEpimerYield (engineering)ChemistryActive ingredientCrystallizationCombinatorial chemistryResolution (logic)SolventConformational isomerismProtocol (science)Biochemical engineeringProcess engineeringComputer scienceEnantioselective synthesisOrganic chemistryMaterials scienceCatalysisMoleculeArtificial intelligenceEngineeringBiologyAlternative medicinePathologyMedicineBioinformaticsMetallurgyAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis