Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
Elana Shaw, Lindsey B. Rosen, Aristine Cheng, Kerry Dobbs, Ottavia M. Delmonte, Elise M. N. Ferré, Monica M. Schmitt, Luisa Imberti, Virginia Quaresima, Michail S. Lionakis, Luigi D. Notarangelo, Steven M. Holland, Helen C. Su
Abstract
Binding levels and neutralization activity of anti-type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
Topics & Concepts
ConvalescenceAutoantibodyMedicineInterferonImmunologyAntibodyDiseaseVirologyInterferon type ICoronavirusCoronavirus disease 2019 (COVID-19)NeutralizationInfectious disease (medical specialty)Internal medicineSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSystemic Lupus Erythematosus Research