Litcius/Paper detail

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

John K. Eaton, Laura Furst, Richard A. Ruberto, Dieter Moosmayer, A. Hilpmann, Matthew J. Ryan, Katja Zimmermann, Luke L. Cai, Michael Niehues, Volker Badock, Anneke Kramm, Sixun Chen, R.C. Hillig, Paul A. Clemons, Stefan Gradl, Claire Montagnon, Kiel E. Lazarski, Sven Christian, Besnik Bajrami, Roland Neuhaus, Ashley Eheim, Vasanthi S. Viswanathan, Stuart L. Schreiber

2020Nature Chemical Biology473 citationsDOIOpen Access PDF

Topics & Concepts

NitrileChemistryGPX4ElectrophileCovalent bondGlutathioneCombinatorial chemistryBiochemistryGlutathione peroxidaseEnzymeOrganic chemistryCatalysisInflammatory mediators and NSAID effectsFerroptosis and cancer prognosisSynthesis and Catalytic Reactions