Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
John K. Eaton, Laura Furst, Richard A. Ruberto, Dieter Moosmayer, A. Hilpmann, Matthew J. Ryan, Katja Zimmermann, Luke L. Cai, Michael Niehues, Volker Badock, Anneke Kramm, Sixun Chen, R.C. Hillig, Paul A. Clemons, Stefan Gradl, Claire Montagnon, Kiel E. Lazarski, Sven Christian, Besnik Bajrami, Roland Neuhaus, Ashley Eheim, Vasanthi S. Viswanathan, Stuart L. Schreiber
Topics & Concepts
NitrileChemistryGPX4ElectrophileCovalent bondGlutathioneCombinatorial chemistryBiochemistryGlutathione peroxidaseEnzymeOrganic chemistryCatalysisInflammatory mediators and NSAID effectsFerroptosis and cancer prognosisSynthesis and Catalytic Reactions