β-carotene regulates cancer stemness in colon cancer <i>in vivo</i> and <i>in vitro</i>
Kyung Eun Lee, Minseo Kwon, Yoo Sun Kim, Yerin Kim, Min Gi Chung, Seung Chul Heo, Yuri Kim
Abstract
BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) is the third most common cancer worldwide and has a high recurrence rate, which is associated with cancer stem cells (CSCs). β-carotene (BC) possesses antioxidant activity and several anticancer mechanisms. However, no investigation has examined its effect on colon cancer stemness. MATERIALS/METHODS: HCT116 cells were subcutaneously injected in xenograft mice and analyzed the effect of BC on tumor formation, tumor volume, and CSCs markers in tumors. RESULTS: as well. CONCLUSIONS: These results suggest that BC may be a potential therapeutic agent for colon cancer by targeting colon CSCs.
Topics & Concepts
CD44Cancer stem cellWnt signaling pathwaySOX2Clonogenic assayColorectal cancerCancer researchCancerStem cellIn vivoCancer cellMedicineIn vitroBiologyInternal medicineSignal transductionCell biologyTranscription factorBiochemistryGeneBiotechnologyAntioxidant Activity and Oxidative StressCancer, Lipids, and MetabolismRetinoids in leukemia and cellular processes