Mixed bases mediated synthesis of thioamides in water
Jiao Li, Xuanhe Ren, Ganzhong Li, Helong Liang, Yajie Zhao, Zhiwu Wang, Heng Li, Bingxin Yuan
Abstract
A mixed bases mediated protocol is developed to synthesize thioamides from N-aryl or N-alkylamide, aldehyde and elemental sulfur in water. This reaction requires no addition of external oxidant and avoids large excess of amides. Various functional groups and pharmaceutically interesting heteroaromatic rings could be introduced via this efficient procedure.
Topics & Concepts
ChemistryAldehydeArylSulfurCombinatorial chemistryOrganic chemistryReaction conditionsCatalysisAlkylSynthesis and Reactivity of Sulfur-Containing CompoundsSynthesis of heterocyclic compoundsQuinazolinone synthesis and applications