Spatial association of surface water quality and human cancer in China
Zixing Wang, Wentao Gu, Xiaobo Guo, Fang Xue, Jing Zhao, Wei Han, Hairong Li, Wangyue Chen, Yaoda Hu, Cuihong Yang, Luwen Zhang, Peng Wu, Yali Chen, Yujie Zhao, Jin Du, Jingmei Jiang
Abstract
Abstract Little is known about the association between surface water quality and cancer incidence, especially in China. Drinking water quality has been linked to the incidence of several cancers in individual-level studies. However, few studies have attempted to examine multiple pollutants and multiple cancers at population level. This study used water monitoring and population-level cancer data from across China to examine spatial associations between water pollutants and types of cancer. We found a “dose–response” relationship between the number of pollutants present at high levels and cancer incidence. These results provide evidence of a nationwide spatial association between water quality and cancer in China. The precise relationship varies with cancers and pollutants. However, the overall consistency of the “dose–response” relationship suggests that surface water quality is an important factor in cancer incidence. Our findings highlight new issues such as the changing effects when different pollutants co-exist and an increasing number of new cancer cases partially attributable to poor water quality. Our work also points to some ways to deal with these challenges.