A novel approach to guide GD2-targeted therapy in pediatric tumors by PET and [<sup>64</sup>Cu]Cu-NOTA-ch14.18/CHO
Nils F. Trautwein, Johannes Schwenck, Christian Seitz, Ferdinand Seith, Eduardo Calderón, S. von Beschwitz, Stephan Singer, Gerald Reischl, Rupert Handgretinger, Jürgen Schäfer, Peter Lang, Bernd J. Pichler, Johannes H. Schulte, Christian la Fougère, Helmut Dittmann
Abstract
Cu-GD2 PET/MRI enables the non-invasive assessment of individual heterogeneity of GD2 expression, which challenges our current clinical practice of patient selection, stratification and immunotherapy application scheme for treatment with anti-GD2 directed therapies.
Topics & Concepts
NeuroblastomaMedicinePositron emission tomographySarcomaImmunohistochemistryOsteosarcomaImmunotherapyImaging agentAntibodyNuclear medicineIn vivoPathologyCancer researchInternal medicineCancerImmunologyBiologyCell cultureGeneticsBiotechnologyNeuroblastoma Research and TreatmentsCAR-T cell therapy researchCancer therapeutics and mechanisms