Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo
Yu He, Yinheng Luo, Lan Huang, Dan Zhang, Huijin Hou, Yue Liang, Shi Deng, Peng Zhang, Shufang Liang
Topics & Concepts
GlycolysisChemistryIn vivoEnzymeSorafenibCell growthBiochemistryMetabolic pathwayKidneyCancer researchPharmacologyBiologyEndocrinologyHepatocellular carcinomaBiotechnologyRenal cell carcinoma treatmentEpigenetics and DNA MethylationCancer, Hypoxia, and Metabolism