Immunopathogenesis of corneal graft rejection
Prafulla K. Maharana, Sohini Mandal, Luci Kaweri, Pranita Sahay, Suman Lata, Mohamed Ibrahime Asif, Ritu Nagpal, Namrata Sharma
Abstract
The most common cause of corneal graft failure is corneal graft rejection (CGR). Although cornea is one of the immune-privileged sites, it can still get a rejection episode due to a breach in its natural protective mechanism. Both anatomical and structural properties of cornea and anterior chamber contribute toward its immune tolerance. Clinically, every layer of the transplanted cornea can get a rejection episode. A proper understanding of immunopathogenesis will help in understanding the various mechanism of CGR and the development of newer strategies for the prevention and management of such cases.
Topics & Concepts
MedicineCorneaGraft rejectionImmune systemMechanism (biology)Corneal graftCorneal transplantationImmunologyOphthalmologyTransplantationSurgeryEpistemologyPhilosophyCorneal surgery and disordersCorneal Surgery and TreatmentsOcular Surface and Contact Lens