The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues
Radha Raman Pandey, Elena Delfino, David Homolka, Adriana Roithová, Kuan‐Ming Chen, Lingyun Li, Giulia Franco, Cathrine Broberg Vågbø, Emmanuel Taillebourg, Marie‐Odile Fauvarque, Ramesh S. Pillai
Abstract
Am) in the hypermethylated cap4 structure of trypanosomatids. Thus, PCIF1 has evolved to function in catalytic and non-catalytic roles.
Topics & Concepts
BiologyRNA polymerase IIMutantRNATranscription (linguistics)Cell biologyMethyltransferaseSmall nucleolar RNAMolecular biologyMethylationBiochemistryGeneGene expressionPromoterNon-coding RNALinguisticsPhilosophyRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research